Lupus or SLE is an autoimmune disorder. That means that the body's immune system mistakenly attacks its own tissue. Several studies show that taking DHEA along with other medications helps improve quality of life for people with lupus, though it probably does not change the overall course of their disease.
Studies using DHEA to treat overweight people have found conflicting results. Animal studies have found DHEA to help reduce body weight. Human studies found that taking DHEA didn't change total body weight. But it did improve total body fat and LDL ("bad") cholesterol. More research is needed.
Since DHEA levels decline with age, some researchers have investigated whether taking DHEA supplements could slow or prevent age-related mental or physical problems. Preliminary results from the DHEAge study in France suggested DHEA may slow bone loss, improve skin health, and improve sex drive in women over 70. People in the study didn't have any improvement in muscle function and strength. Another study found that men and women over 60 who took DHEA for 2 years didn't have any improvement in bone density, muscle strength, insulin sensitivity, or quality of life.
Preliminary studies show DHEA supplements raised levels of some hormones in postmenopausal women. However, DHEA supplementation in healthy pre- and postmenopausal women is controversial. Clinical studies show conflicting results as to whether DHEA can improve sexual function, metabolism, and overall well being. More studies are needed to determine whether DHEA is safe and effective.
Most DHEA supplements are produced in laboratories from diosgenin, a plant sterol extracted from Mexican wild yams (Dioscorea villosa). Some extracts from wild yams are marketed as "natural DHEA." Advertisers claim that these "natural" extracts are converted into DHEA by the body. But this is not true. Your body can't covert those extracts into DHEA. For this reason, it is best to look for labels that list DHEA rather than diosgenin or wild yam extract.
Gordon C, Grace E, Emans SJ, Goodman E, Crawford MH, Leboff MS. Changes in bone turnover markers and menstrual function after short-term oral DHEA in young women with anorexia nervosa. J Bone Miner Res. 1999;14(1):136-145.
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Not for use by individuals under age of 18 years. Do not use if pregnant or nursing. Consult a physician or licensed qualified healthcare professional before using this product if you have, or have a family history of prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug or over-the-counter drug. Do not exceed the recommended serving. Exceeding the recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified healthcare professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. Keep out of reach of children.
An alternate strategy is to combine a standard multivitamin or prenatal with a separate methylfolate supplement. If doing so, it may be better to avoid multivitamins that contain a high dose of folic acid, because there is a possibility that this in fact inhibits the use of active folate (although this is a controversial point and may only matter for those with certain MTHFR variants).
In another small study of overweight patients with PCOS, inositol supplementation reduced insulin levels and restored menstrual cycle regularity for patients with irregular cycles. Another small study of PCOS patients with insulin resistance concluded that inositol induced ovulation in 61% of patients, resulting in pregnancy for over one-third of subjects. And several studies (1, 2) have demonstrated that inositol could be nearly as, if not more, effective for those hoping to conceive with PCOS than metformin, the common drug of choice for insulin resistance.
It is very important that you do not take DHEA unless you are prescribed the medication by your doctor. DHEA is often sold as a dietary supplement, but these over-the-counter tablets are not regulated and may be ineffective. You must not treat yourself with DHEA unless it is prescribed to you by your doctor. If your doctor does decide upon DHEA as part of your lupus treatment, you will need to obtain it from a compounding pharmacy. The dosage given for the treatment of certain lupus symptoms is 200 milligrams.
DHEA may interfere with a wide variety of prescription medications, over-the-counter medications, and other herbal supplements. DHEA may also interact with a recent flu vaccination or with alcohol consumption. As a result, great care should be taken before supplementing DHEA levels. No prescription medication should be taken with DHEA without consulting with the prescribing physician. The following list is illustrative only.
Independent of age, serum levels of DHEA-S appear to be positively correlated with healthier psychological profiles - executive function, working memory, attention, concentration, enjoyment of leisure activities and overall stress-buffering effect . Imbalance in the DHEA pool tends to be associated with distress and psychopathology, such as depression, anxiety, bipolar disorder, eating disorders, PTSD and perceived stress   . Specifically, DHEA-S levels are inversely correlated with hyperactivity, suggesting a possible protective role in the etiology of ADHD . Low DHEA-S levels have been reported in young patients with anorexia nervosa. Moreover, lower DHEA levels go hand-in-hand with the degree in severity of depression . And on the flip-side, too-high levels have been detected in patients with mania . Elevated DHEA-S and reduced cortisol have also been reported in patients with PTSD .
While DHEA is available over the counter in health food stores, it is best used under medical supervision with the goal of restoring low levels to the physiological range. When treating a patient with low androgen symptoms and low DHEA-S levels, it is important to consider the route of hormone administration (e.g., most common routes are oral, sublingual, topical, and vaginal) and testing options for measuring DHEA or DHEA-S (saliva, blood spot, serum, or urine).
DHEA production peaks in your mid-20s and gradually declines with age. DHEA levels may drop to less than 20% of their peak value over the next 40 to 60 years of your life. Low levels are linked to several conditions, such as depression and sexual dysfunction.
This wealth of incontrovertible medical evidence has not stopped the government from erecting regulatory barriers that would deny you the ability to replenish DHEA and pregnenolone to youthful levels.
DHEA is the major circulating steroid in human blood and it is a central intermediate in the metabolic pathway of sex steroid hormone formation. Although the specific effect of DHEA is still unclear it was demonstrated that DHEA modulates several physiologic processes including metabolism and cardiovascular function. Furthermore, a profound immunomodulatory effect of DHEA was reported. Several data demonstrate the beneficial effect of DHEA in situations of critical illness including trauma hemorrhage and sepsis. Accordingly DHEA improved the survival rate and clinical situation in several animal models of trauma hemorrhage and systemic inflammation. This effect was paralleled by profound changes of immunologic parameters, organ function, and heat shock protein production. Therefore, it was claimed that DHEA may be a new alternative/additive in the treatment of trauma and sepsis. In line, DHEA is a frequently used drug in the field of anti-aging medicine, it is an over-the-counter drug in several countries, and it was reported that DHEA medication is free of major side effects. Therefore, DHEA could easily be used in a clinical trial investigating its effects in critical ill patients. This article reviews the reported effects of DHEA on the base of the literature with the specific focus on trauma and sepsis/critical illness including its clinical perspectives.
Levels of DHEA can decline with age as part of the natural aging process. DHEA is a hormone that is produced in our bodies by the adrenal glands and the levels of this hormone may begin to decline after the age of 30. Supplementing may help replenish what our bodies lose over time.
Lower levels of DHEAS are associated with higher risk of conditions such as diminished immunity , increased risk of cardiovascular disease  and stroke , and unstable blood sugar levels . Measuring levels of DHEAS is also used as a clinical indicator of different conditions related to pituitary and adrenal function. Low levels of DHEAS in the blood are linked to decreased pituitary and adrenal function, which can cause many health problems for women, including weakness and fatigue, difficulty in controlling weight, menstrual irregularity, and infertility. High DHEAS levels are associated with overactive adrenal glands, polycystic ovary syndrome, and early puberty. These conditions can also lead to difficulty in controlling weight, menstrual irregularity, and infertility. Additional symptoms in women with overactive pituitary and adrenal glands include acne and excess hair growth all over the body (hirsutism).
Warning: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS OR WOMEN.Consult a physician before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. Keep out of reach of children. 781b155fdc